Study Evaluating Potential Pharmacokinetic (PK) Interaction Between Lecozotan and Digoxin

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Primary: To evaluate the effects of multiple doses of lecozotan SR on the PK profile of a single dose of digoxin in healthy adult subjects.

Secondary: To assess the safety and tolerability of the coadministration of lecozotan SR and digoxin.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
• Treatments: Digoxin

Criteria

Inclusion Criteria:

• Women of non childbearing potential and men aged 18 to 55 years at screening.

• Body mass index (BMI) in the range of 18 to 30 kg/m2 and body weight 50 kg (BMI = weight (kg)/[height (m)]

Exclusion Criteria:

• Presence or history of any disorder that may prevent the successful completion of the study.

• Any clinically important deviation from normal limits in physical examination, vital signs or clinical laboratory test results.