Study Of 90mg Of GW274150 In Subjects Over 50 Years, Who Have Rheumatoid Arthritis (RA)
Status:
Completed
Trial end date:
2005-09-01
Target enrollment:
Participant gender:
Summary
This is a study of GW274150, an iNOS (inducible nitric oxide synthase) inhibitor to
investigate safety, tolerability and pharmacokinetics (PK) in the rheumatoid arthritis (RA)
population (greater than 50 years). Safety, tolerability and PK of GW274150 in an adult and
elderly population have not yet been determined. Therefore this study is designed to ensure
that 90mg GW274150 will be safe and well-tolerated in this adult and elderly RA patient
population on methotrexate. The assessments will include pharmacokinetics (PK), liver
function tests and creatinine clearance.
This study will provide confidence that a single 90mg dose of GW274150 results in exposure in
RA subjects similar to that expected from healthy volunteers and asthmatics.