Overview

Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

Status:
Recruiting

Trial end date:
2029-08-30

Target enrollment:

Participant gender:

Summary

This is an open-label, Phase 1/2 multicenter dose escalation study in pediatric patients with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 2) in patients with primary brain tumors harboring NTRK1/2/3 or ROS1 gene fusions, and extracranial solid tumors harboring NTRK1/2/3 or ROS1 gene fusions.

Phase:

Phase 1/Phase 2

Details

Lead Sponsor:

Hoffmann-La Roche
Ignyta, Inc.

Treatments:

Entrectinib