Study Of Single Doses Of PF-06291826 (Tafamidis) In Japanese And Western Subjects

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is the following:

• To evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered tafamidis in Japanese and Western healthy volunteers at single dose.

• To compare Japanese and Western PK profiles.

• Determine the PD stabilization effect of tafamidis on human transthyretin (TTR) in a validated ex vivo assay.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pfizer

Criteria

Inclusion Criteria:

• Healthy male or females.

• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2.

Exclusion Criteria:

• Pregnant or nursing females.

• Females of childbearing potential who are unwilling or unable to use an acceptable method of contraception.