Study Of Two Non-Myeloablative Stem Cell Transplant Strategies For Low-Grade Lymphoma And CLL
Status:
Terminated
Trial end date:
2003-01-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
Peripheral stem cell transplantation may be able to replace immune cells that were destroyed
by chemotherapy or radiation therapy. Sometimes the transplanted cells are rejected by the
body's normal tissues. Cyclosporine, mycophenolate mofetil, methotrexate, and tacrolimus may
prevent this from happening.
PURPOSE: Randomized phase II trial to compare the effectiveness of fludarabine plus
total-body irradiation with that of combination chemotherapy followed by donor peripheral
stem cell transplantation in treating patients who have relapsed non-Hodgkin's lymphoma or
chronic lymphocytic leukemia.
Phase:
Phase 2
Details
Lead Sponsor:
Simmons Cancer Center University of Texas Southwestern Medical Center