Study for the Effectiveness of Intensive Therapy Aiming at a Remission of Diabetic Nephropathy

• Status: Unknown status
• Trial end date: 0000-00-00
• Target enrollment: 600
• Participant gender: Both

Summary

Study for the effectiveness of intensive therapy aiming at the remission of diabetic nephropathy

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Okayama University
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Last Updated: 2007-01-15

Criteria

Inclusion Criteria:

• Type 2 diabetes mellitus

• Urinary albumin/creatinine ratio >= 300mg/gCr

• Serum creatinine level <2.5mg/dL through the observation period

• Patients whose consent is obtained at age >20 years or =<75 years

Exclusion Criteria:

• Type 1 diabetes mellitus

• Hereditary diabetes mellitus or secondary diabetes mellitus

• Non-diabetic nephropathy

• Familial hypercholesterolemia

• Secondary hypertension

• Unstable angina pectoris

• Myocardial infarction

• Cerebral hemorrhage

• Life-threatening disease such as malignant tumor

• History of angioedema

• Under LDL-apheresis by a adsorbent with dextran sulphate cellose

• Biliary obstruction

• Severe hepatopathy

• Hypergasia of hepatic metabolism such as acute hepatitis

• Exacerbation of chronic hepatitis

• Cirrhosis

• Hepatic cancer

• Jaundice

• History of hypersensitivity against ACE inhibitors

• History of hypersensitivity against ARB

• History of hypersensitivity against HMG-CoA reductase inhibitors

• Pregnant, lactating, and probably pregnant patients

• Patients who want to become pregnant during the study period

• Patients judged as being inappropriate for the subjects