Study of 6-Thioguanine in Combination With 6-Mercaptopurine During Maintenance Therapy of Childhood Lymphoma
Status:
Withdrawn
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
The purpose of this phase 1-2 study is to explore the applicability of supplementing standard
methotrexate/6-mercaptopurine (MTX/6MP) maintenance therapy of children with non-Hodgkin
lymphoma with 6-thioguanine (6TG).
The investigators hypothesize that addition of 6TG to 6MP-based maintenance therapy of
patients with high TPMT activity will mimic the more favourable thiopurine metabolism of
patients with low TPMT activity and ultimately reduce relapse rates.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Kjeld Schmiegelow
Collaborators:
Aalborg Universitetshospital Aalborg University Hospital Aarhus University Hospital Skejby Odense University Hospital