Study of Acarbose in Longevity

• Status: Completed
• Trial end date: 2019-12-26
• Target enrollment: 0
• Participant gender: Male

Summary

The investigators are studying the effects of acarbose on muscle and adipose gene transcription in older adults.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Acarbose

Criteria

Inclusion Criteria:

• Male

• age >60 years

• impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)

Exclusion Criteria:

• cancer

• heart failure

• COPD

• inflammatory conditions

• eGFR<45

• active liver disease

• poorly controlled hypertension

• epilepsy

• recent cardiovascular disease event (last 6 months)

• inflammatory bowel disease

• history of bariatric or other gastric surgery

• cigarette smoking

• serious substance abuse.

• Treatment with drugs known to influence glucose metabolism

• Hypersensitivity to acarbose or any component of the formulation.

• Treatment with anti-coagulant medications or anti-platelet drugs