Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Augusta University
• Treatments: Amiloride

Criteria

Inclusion Criteria:

• Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP between 80 to 89 mmHg during screening visit. BP will be measured manually tree times at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair. The average of last two BP measurements will be taken into consideration.

• Male or female of Caucasian or African-American origin.

• No history of any major past and current medical illness (such as diabetes, renal disease, liver disease etc.)

• Not taking any medication that affects blood pressure.

Exclusion Criteria:

• HbA1C > 7.0 % during screening visit.

• Serum potassium > 5.5 mEq/L during screening and/or any testing visit due to risk of developing hyperkalemia.

• Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or any testing visit due to risk of developing renal dysfunction.

• Female having positive pregnancy test during screening and/or any testing visit.