Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to evaluate the effects of insulin resistance on brain function in women with Polycystic Ovary Syndrome (PCOS). PCOS affected women will be evaluated prior to and following 4-month treatment with Metformin. Additionally, brain function in women with PCOS will be compared to the brain activity in normal control subjects with regular menstrual cycles.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Treatments: Insulin; Metformin

Criteria

Inclusion Criteria:

• Insulin-resistant PCOS (Arm: PCOS Affected Women)

• Irregular menstrual cycle (Arm: PCOS Affected Women)

• Hyperandrogenism (Arm: PCOS Affected Women)

• Regular menstrual cycles (Arm: Normal Controls)

• Normal hormonal levels (Arm: Normal Controls)

• Lack of hirsutism (Arm: Normal Controls)

• Acne-free (Arm: Normal Controls)

• Candidates are BMI-matched and screened for insulin resistance prior to inclusion. (Arm: Normal Controls)

Exclusion Criteria:

• Left handedness

• Acute medical illness

• Uncorrected thyroid disease

• Diabetes renal

• Cardiac or pulmonary insufficiency

• Active liver disease

• Neurological disease

• Current psychiatric illness

• Claustrophobia

• Contraindications to MRI

• Smoking

• Use of hormones

• Centrally acting or insulin sensitizing mediations

• Allergy to any opioid medication

• Substance abuse

• Pregnancy

• BMI >35.