Overview

Study of Decitabine and Tetrahydrouridine (THU) in Patients With Sickle Cell Disease

Status:
Completed
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
The purposes of this study are to observe if oral tetrahydrouridine and decitabine can increase fetal hemoglobin levels and improve the symptoms of sickle cell disease, and to monitor how patient's bodies react to oral tetrahydrouridine and decitabine.
Phase:
Phase 1
Details
Lead Sponsor:
The Cleveland Clinic
Yogen Saunthararajah
Collaborator:
University of Illinois at Chicago
Treatments:
Azacitidine
Decitabine
Tetrahydrouridine