Overview

Study of Dexmedetomidine in Spine Surgery

Status:
Completed
Trial end date:
2015-05-01
Target enrollment:
0
Participant gender:
All
Summary
The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups. The investigators plan to document the intraoperative opioid requirements, time to first dose of opioids postoperatively and total opioid consumption in the first 24, 48 and 72 hours. The incidence of intra and postoperative complications will be assessed.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Virginia
Treatments:
Dexmedetomidine
Methadone
Criteria
Inclusion Criteria:

- Age 18-80 years of age

- Elective multi-level thoracic and/or lumbar spine surgery requiring SSEP, EMG or MEP
monitoring

Exclusion Criteria:

- Emergency spine surgery

- Age < 18 years

- Pregnant patients

- Advanced heart block: Mobitz type II block or atrio-ventricular dissociation in a
previous EKG.

- Any individual with stage 4 or greater chronic kidney disease (eGFR< 30 ml/min) and/or
requiring dialysis or liver failure defined as a history of cirrhosis or fulminant
hepatic failure

- Any individuals on preoperative methadone therapy

- Preoperative dexmedetomidine use

- Preoperative systolic hypertension defined by a systolic blood pressure greater than
150 mmHg in the surgical admission suite

- Enrolled in another study within 30 days