The investigators will conduct a prospective randomized double blind study comparing
methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in
two randomized groups. The investigators plan to document the intraoperative opioid
requirements, time to first dose of opioids postoperatively and total opioid consumption in
the first 24, 48 and 72 hours. The incidence of intra and postoperative complications will be
assessed.