Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule

• Status: Recruiting
• Trial end date: 2025-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A. treated with chemotherapy immediately, B. follow up until hCG level met FIGO diagnostic criteria of GTN (B1) or hCG level declined to normal spontaneously (B2). Lung nodule <1.0cm will directly treated as group C

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Women's Hospital School Of Medicine Zhejiang University

Criteria

Inclusion Criteria:

1. pathologic confirmed hydatidiform mole

2. the lung nodule was detected by lung CT at the suction evacuation of molar pregnancy or during weekly hCG surveillance and lung metastasis cannot be excluded

3. the hCG level do not meet FIGO diagnostic criteria of GTN

4. good compliance

5. consent informed

Exclusion Criteria:

1. history of lung nodule

2. lung nodule was conformed as other diseases such as Tuberculosis, pneumonia

3. already accepted with chemotherapy or hysterectomy

4. pathologic confirmed GTN

5. immunosuppressive diseases status or take immunosuppressive drugs

6. Participating in other clinical trials

7. unable or unwilling to sign informed consent

8. cannot or unwilling to comply with research requirements