Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity
Status:
Unknown status
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Obesity is often accompanied by insulin resistance and/or hyperinsulinemia. Acanthosis
nigricans (AN) is a skin condition commonly present on the neck of obese children. Metformin
is a useful drug for conditions characterized by insulin resistance.The aim of this study is
to compare the efficacy of metformin versus placebo on AN lesions of the neck as well as
their effects on metabolic and anthropometric variables in a sample of obese children. This
is a 12-week randomized, double-blind randomized trial involving obese children with AN to
receive either metformin or placebo.
Evaluations will be performed every three weeks. Clinical, histological and colorimetric
assessments of AN lesions will be compared initially and at the conclusion of the study.