Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients

• Status: Terminated
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this project is to determine if task-activated fMRI is sensitive to the central cholinergic deficit associated with Mild Cognitive Impairment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Rivastigmine

Criteria

Inclusion Criteria:

• Diagnosis of amnestic MCI

• In good general health with no diseases expected to interfere with the study

• Ability to undergo MRI

• Fluent in English

• Stable prescription dosages 1 month prior to testing

• Carrier of the APOE e4 allele (determined by blood draw at screening visit)

Exclusion Criteria:

• Neurological illness/conditions

• Medical illnesses/conditions that may affect brain function

• Prior history of use of any cholinesterase inhibitor

• Instable or severe cardiovascular disease or asthmatic condition