Overview

Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure

Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
0
Participant gender:
All
Summary
High normal blood pressure, also called prehypertension, is a significant problem. High uric acid in the blood, the same thing that causes gout, may cause higher blood pressures. The investigators plan to monitor the effects of the drug febuxostat(trade name Uloric) on blood pressure and stiffness of the main blood vessels and see if lowering uric acid has any effect.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of California, San Diego
Treatments:
Febuxostat
Criteria
Inclusion Criteria:

- Prehypertensive male and female subjects with SBP =120-140 mmHg or DBP =80-90 mmHg (as
determined by seated office BP).

- Plasma uric acid level ≥5 mg/dl

- Ages 18-50

- non-smokers

- Subjects will need to remain in the San Diego area for the duration of the study and
be accessible by telephone or email.

Exclusion Criteria:

- no current smoking in the prior 6 months.

- Any history of any serious medical conditions requiring close monitoring from
physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus.
Participants not currently under the care of a physician for these conditions will be
eligible for the study.

- Any history of gout, hypertension, hypercholesterolemia, morbid obesity.

- Any history of use xanthine oxidase inhibitors, antihypertensives, antiglycemic, and
cholesterol lowering medications

- any history of illicit drug use within the last 6 months