Study of Glutamate and Glutamine Metabolism in Burn Patients Receiving Enteral or Parenteral Nutrition

• Status: Withdrawn
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to understand how the body uses amino acids in burned patients during the time they cannot eat normally. Amino acids occur naturally in the body and the food we eat. The body combines amino acids to make protein. It uses the proteins to do things such as heal wounds, fight infection, and provide energy. We are studying two ways of receiving nutrition: through a vein or through a tube. We are also studying two different types of food: with or without glutamine. The results of this study will be used to determine the best type and way to supply nutrients during a severe burn injury. We hope to learn how to help the body use nutrients more efficiently to better repair wounded tissues and recover earlier from injury.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: National Institutes of Health (NIH)

Criteria

Inclusion Criteria:

• One or more of the following:

• 5% Total Body Surface Area Thermal Burn

• Inhalation Injury

• Resting Energy Expenditure of >15% of the predicted Basal Metabolic Rate Using Harris-Benedict.

• Receiving Enteral or Parental Nutritional Support

Exclusion Criteria:

• Pre-existing:

• Thyroid disease

• Congestive Heart Failure (Ejection fraction <20%)

• Malignancy currently under treatment

• Medical conditions requiring glucocorticoid treatment

• Decision not to treat because of severity of injury

• Presence of Anoxic brain injury with no expectation for recovery

• Self-Inflicted thermal injury

• Ileus, gut paralysis, or facial injuries

• No NG or OG tube as part of their clinical care