Study of Glycemic Control on Liver Transplantation Outcomes

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Many but not all studies have shown improvement in morbidity and mortality with intensive glycemic management postoperatively. In this study, the investigators propose to determine whether improved glycemic control using intensive insulin treatment immediately postoperatively will improve outcomes in patients undergoing liver transplant using a prospective, controlled, randomized, parallel-group study design targeting two different glucose levels, 140 and 180 mg/dL.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

1. Require Liver Transplantation

2. Age 18 - 80

3. Able to give informed consent personally or via a family member who has appropriate authorization to do so if patient unconscious.

4. Expected survival following transplantation for > 1 year.

5. Glucose level over 180 mg/dL postoperatively

Exclusion Criteria:

1. Inability of patient or family member to give informed consent

2. Not expected to survive for > 1 year following liver transplantation.

3. Previous liver transplantation

4. Acute liver failure

5. Living related donor