Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
Status:
Completed
Trial end date:
2008-11-11
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Confirm the efficacy demonstrated in a pilot study using high dose
cyclophosphamide in patients with severe aplastic anemia.
II. Determine whether the addition of filgrastim (G-CSF) to high dose cyclophosphamide
shortens the time to recovery in these patients.
III. Determine whether this regimen is efficacious in treating paroxysmal nocturnal
hemoglobinuria.
Phase:
Phase 2
Details
Lead Sponsor:
Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins