Study of Human Regular U-500 Insulin in Adult Participants With Type 2 Diabetes

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of this study is to compare the effectiveness of Human Regular U-500 Insulin three times a day versus twice a day.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eli Lilly and Company
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Major Inclusion Criteria:

• Have type 2 diabetes mellitus (World Health Organization [WHO] Classification of Diabetes)

• Have a body mass index (BMI) ≥25 kilogram per square meter (kg/m^2)

• Have Glycated Hemoglobin A1c (HbA1c) ≥7.5% and ≤12.0%, as measured by the central laboratory at entry

• Current U-100 insulin/analogue users on >200 and ≤600 units per day for ≥3 months at study entry and reconfirmed at randomization

• Have a history of stable body weight for at least 3 months prior to study entry

• Concomitant medications may include metformin (MET), dipeptidyl peptidase-4 (DPP-4) inhibitors approved for use with insulin at time of study entry (for example, sitagliptin, saxagliptin, and linagliptin), pioglitazone, and/or sulfonylureas (SUs)/glinides (repaglinide or nateglinide). Participant's oral antihyperglycemic drug (OAD) dose(s) must have been stable for ≥3 months

Major Exclusion Criteria:

• Have type 1 diabetes mellitus or other types of diabetes mellitus apart from type 2 diabetes mellitus

• Have obvious clinical signs or symptoms of liver disease, acute or chronic hepatitis, or alanine aminotransferase or aspartate aminotransferase levels ≥3 times the upper limit of the reference range

• Have chronic kidney disease stage 4 and higher or history of renal transplantation

• Have history of more than 1 episode of severe hypoglycemia within the 6 months prior to study entry

• Have received insulin by continuous subcutaneous insulin infusion in the 3 months prior to study entry

• Have received U-500R in the 3 months prior to study entry

• Have had a blood transfusion or severe blood loss within 3 months prior to study entry or have known hemoglobinopathy, hemolytic anemia, or sickle cell anemia

• Are taking chronic systemic glucocorticoid therapy or have received such therapy within the 4 weeks immediately prior to study entry

• Have an irregular sleep/wake cycle

• Have used rosiglitazone, once- or twice-daily glucagon-like peptide-1 (GLP-1) receptor agents, pramlintide, or other injectable or oral antihyperglycemic therapy not listed in the inclusion criteria in the 3 months prior to study entry. Participants may not have used once-weekly GLP-1 receptor agents in the 4 months prior to study entry

• Have used any weight loss drugs in the 3 months prior to study entry

• Have a history of bariatric surgery

• Have a history of malignancy other than basal cell or squamous cell skin cancer

• Have New York Heart Association (NYHA) Class III or IV per NYHA Cardiac Disease Functional Classification

• Are breastfeeding or pregnant, or intend to become pregnant during the course of the study, or are sexually active women of childbearing potential not actively practicing birth control by a method determined by the investigator to be medically acceptable