Study of Ketorolac Versus Opioid for Pain After Endoscopy

• Status: Completed
• Trial end date: 2021-08-01
• Target enrollment: 0
• Participant gender: All

Summary

A double blind randomized controlled trial designed to compare pain control and safety with ketorolac and oxycodone in the post-operative setting for patients undergoing ureteroscopy for treatment of urinary stones. Patients are followed for five days after their surgery as they record their pain scores, medication utilization, and stent related symptoms.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Ketorolac; Ketorolac Tromethamine; Oxycodone

Criteria

Inclusion Criteria:

• Patients with kidney or ureteral stones confirmed on imaging (CT of the abdomen pelvis) and who elect for definitive treatment via unilateral ureteroscopy at one of two hospital sites within a tertiary care institution

• Patients who post-operatively receive a unilateral ureteral stent

• Capable of giving informed consent

• Capable and willing to fulfill requirements of the study

Exclusion Criteria:

• Active or history of peptic ulcer disease, gastrointestinal bleeding or perforation

• History of coronary artery bypass graft surgery

• History of a bleeding disorder

• GFR less than 60 mL/min/1.73m2 (MDRD equation)

• Chronic use of opioid or other pain medication including NSAIDs (greater than 12 weeks)

• Known allergy to either ketorolac or oxycodone

• Known or suspected pregnancy

• Solitary kidney

• Patients taking anticoagulant medication or antiplatelet medication (e.g. warfarin, clopidogrel, pradaxa, rivaroxaban, apixaban etc).

• Inability to give informed consent or unable to meet requirements of the study for any reason