Study of Lisdexamfetamine Sulfate to Treat Cognitive Dysfunction in Multiple Sclerosis
Status:
Completed
Trial end date:
2011-08-01
Target enrollment:
Participant gender:
Summary
Amphetamines have been shown to improve cognition but its use is limited due to its side
effects. Lisdexamfetamine is an amphetamine pro-drug, minimizing these effects and has been
safely used in children and adults with Attention Deficit Hyperactivity Disorder (ADHD). The
investigators hypothesize that lisdexamfetamine may improve cognitive abilities in MS
patients with documented cognitive dysfunction. Because lisdexamfetamine is a stimulant its
positive effects should be observed primarily in the domains of processing speed and working
memory. The investigators therefore propose a study in which the primary objective will be to
assess the efficacy of lisdexamfetamine in improving attention and processing speed in MS.
The secondary objectives will be (a) the assessment of the safety and tolerability of
lisdexamfetamine in the MS population, and (b) to test for effects of the drug on other
cognitive domains, depression, and self and informant reports of cognitive and executive
function demanding activities and behaviors.