Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

We previously hypothesized that the excess of Anti-Mullerian Hormone (AMH) at the level of ovarian selectable follicles could be involved in the follicular arrest of Polycystic Ovary Syndrome (PCOS), mainly through inhibition of FSH effect on aromatase expression.In this study, we plan to investigate whether a drop in the serum AMH level would be concomitant to the appearance of a dominant follicle induced by administration of mild amounts of exogenous FSH in women with PCOS.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Lille
• Collaborator: Organon

Criteria

Inclusion Criteria:

• normal sperm analysis in the partners and normal hysterosalpingography in all patients

• PCOS defined by Rotterdam criteria

• resistance to clomiphene citrate, i.e. no ovulation at 150 mg/day or no pregnancy after 6 ovulatory cycles

• informed consent before inclusion

Exclusion Criteria:

• on-going pregnancy

• age<18 or >40 yr.

• unability to understand the treatment protocol

• other medications

• any co-existent morbid condition contra-indicating a pregnancy