Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain, confusion, and breaks in normal sleep cycles have been challenges commonly faced by patients after undergoing joint surgeries. To address these issues, melatonin, an inexpensive over-the-counter supplement, has shown in previous to help manage sleep disorders, prevent and treat post-operative confusion in patients over 70 years of age, and reduce pain. The purpose of this study is to establish whether melatonin can aid in reducing pain and post-operative confusion and improve sleep quality after total knee replacement

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital for Special Surgery, New York
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Patients 18-90 years old undergoing elective, primary total knee replacement

• American Society of Anesthesiologists (ASA) Physical Status I-III

• Epidural anesthesia/Patient Controlled Analgesia candidate

Exclusion Criteria:

• Mental impairment

• Pre-operative use of benzodiazepines, narcotics, or prescription/over-the counter (OTC) sleep aids

• Pre-operative use of calcium channel blockers

• Insomnia

• Recent drug or alcohol abuse

• Psychiatric disorders other than anxiety, including depression

• Diabetes