Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

OBJECTIVES: I. Compare the clinical status of pregnant vs non-pregnant women with cystic fibrosis.

II. Determine glucose tolerance during each trimester of pregnancy in these women.

III. Evaluate peripheral insulin sensitivity in these women. IV. Evaluate whole body protein turnover and hepatic glucose production in these women.

V. Determine resting energy expenditure in these women.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Center for Research Resources (NCRR)
• Collaborator: University of Utah

Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

• Diagnosis of cystic fibrosis (CF) and pregnant OR Age, weight, and body mass index matched non-pregnant CF woman or pregnant non-CF woman

• No infection with Burkholderia cepacia

• FEV1 at least 60%

--Prior/Concurrent Therapy--

• At least 3 weeks since prior corticosteroids

--Patient Characteristics--

• Hepatic: No more than one transaminase level greater than 10% above normal

Other:

Pregnant non-CF controls:

• No cigarette smokers

• No history of gestational diabetes mellitus

• No type 1 or 2 diabetes

• No other chronic illness