Study of Metformin Pharmacogenetics in Twins

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Southern Denmark
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Age 18-40 years

• Both twins has to be included

• Dizygotic twin pairs has to be same sex

• Informed consent given

• Healthy condition

Exclusion Criteria:

• Chronical/daily alcohol abuse

• Hypersensitivity to metformin

• Ingestion of drugs containing topiramate or x-ray contrast fluids

• For women: Positive pregnancy test/breastfeeding at the beginning of the trial. No use of safe anticonceptives