Study of Mitomycin-C Application in Laryngotracheal Stenosis

• Status: Terminated
• Trial end date: 2018-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, prospective, double-blind, placebo-controlled clinical trial of the use of mitomycin-C topical application as an adjunctive treatment in the endoscopic surgical treatment of patients with laryngotracheal stenosis. We hypothesize that the use of mitomycin-C improves patient outcome in the endoscopic surgical treatment of laryngotracheal stenosis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Mitomycin; Mitomycins

Criteria

Inclusion Criteria:

• Patients with laryngotracheal stenosis, including subglottic stenosis or tracheal stenosis

• Patients with disease amenable to treatment with endoscopic CO2 laser radial incisions and balloon dilation

• Age greater than or equal to 18 years

Exclusion Criteria:

• Age less than 18 years

• Pregnancy

• Patients with glottic and supraglottic stenosis

• Patients with disease not amenable to treatment with endoscopic CO2 laser radial incisions and balloon dilation

• Patients with cartilaginous subglottic or tracheal stenosis