Study of Mood Effects of Varenicline (Chantix) in Depressed Outpatient Smokers

• Status: Completed
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will assess whether varenicline (chantix) has antidepressant properties when used in addition to other psychiatric medication. It will also assess whether varenicline improves the inability to feel pleasure (i.e. anhedonia), and if it is well-tolerated when used with psychiatric medications.

Enrolled patients will be assessed for improved mood, improved anhedonia, overall sense of health, side effects as well as tobacco use for 6-8 weeks.

Medication will be provided free of charge.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Butler Hospital
• Collaborator: Brown University
• Treatments: Varenicline

Criteria

Inclusion Criteria:

1. Meets DSM-IV symptoms criteria for a mood disorder including major depression [unipolar or bipolar], depressive disorder NOS, dysthymia, adjustment disorder with depressed mood, or substance-induced mood disorder.

2. Failed to achieve full symptom remission with previous pharmacotherapy.

3. Current tobacco users.

4. Able to give written, informed consent.

Exclusion Criteria:

1. Past adverse reaction to varenicline.

2. Renal failure or dialysis.

3. Current pregnancy or breastfeeding.