Study of Morphine in Postoperative Infants to Allow Normal Ventilation
Status:
Completed
Trial end date:
1998-07-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Compare nonmechanically ventilated infants who receive morphine
postoperatively as intermittent intravenous bolus doses or as a continuous intravenous
infusion targeted to reach a steady-state concentration.
II. Assess ventilation (blood gases, continuous oximetry, and CO2 response curves) and
analgesia (infant pain score) between the two treatment groups of infants.
III. Compare ventilation parameters (blood gases, CO2 response curves, and time to wean from
assisted mechanical ventilation) in cyanotic and acyanotic infants after thoracotomies.