Study of Multiplexed Heptapeptides for Detection of Neoplasia in the Esophagus
Status:
Completed
Trial end date:
2019-02-04
Target enrollment:
Participant gender:
Summary
The overall aim of this feasibility study is to develop new technologies for improved
detection of Barrett's neoplasia using the scanning fiber endoscope(SFE) multiplexed imaging
system. This study will combine the use of fluorescent-labeled peptides that bind
specifically to pre-cancerous mucosa in the esophagus for use as novel imaging agents to
guide endoscopic biopsy or endoscopic mucosal resection (EMR). This Phase 1 study will be
used to provide early evidence of efficacy for the topical application of a panel of two
peptides that bind to molecular targets that are specific for esophageal dysplasia. A panel
is needed because cancer in the esophagus is genetically heterogeneous. The study will look
at peptide binding in subjects with known or suspected Barrett's esophagus.