This study will investigate the safety, efficacy and dose-response of NPO-13 in subjects with
moderate to severe colonic spasm during colonoscopy. An intraluminal spraying of NPO-13 dosed
up to twice into ascending or sigmoid colon. The colonic spasm will be assessed by an
independent committee using recorded video images. The study consists of a screening visit
window, 1-day treatment phase and 1-week follow-up phase.