Study of Nifedipine GITS and Candesartan Combination Compared to Monotherapy in Patients With Essential Hypertension
Status:
Completed
Trial end date:
2012-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the blood pressure lowering responses of various
dose combinations of nifedipine GITS and candesartan as compared to treatment with each
component on their own (monotherapy) and placebo (a look-alike tablet without active
ingredient). The drugs - nifedipine GITS and candesartan - which are being investigated are
currently approved for use in patients with essential hypertension alone or together with
other antihypertensive drugs (combination therapy), but the optimal dose of nifedipine GITS
and candesartan used together in the treatment of essential hypertension has not been
established yet. In this study patients will be treated with various doses of nifedipine GITS
and/or candesartan or placebo. These different regimens will be administered once a day and
will be assessed based on their blood pressure lowering effects (mean sitting diastolic blood
pressure) in subjects with mild to moderate essential hypertension.