Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal

• Status: Terminated
• Trial end date: 2008-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this trial is to compare the ability of two doses of OT-551 ophthalmic solution and drug-free solution to safely and effectively prevent or delay the progression of nuclear cataracts that frequently develop as a result of vitrectomy (surgery for retina repair), thereby avoiding the need for a second surgery (cataract removal). Victrectomies involve removal of the jelly-like substance (vitreous) that is located in a cavity behind the lens.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Othera Pharmaceuticals
• Treatments: Ophthalmic Solutions; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Imminent vitrectomy to repair macular holes or puckers

• Ability to be screened for eligibility and begin dosing 7-10 days in advance of the surgery

• Best corrected ETDRS visual acuity equivalent to Snellen 20/400 or better in the surgical eye and 20/100 or better in the fellow eye

Exclusion Criteria:

• Artificial lens or no lens in the surgical eye

• Cataract (greater than slight opacity or thickness) in the surgical eye

• Any other retinal abnormality which may be vision-threatening

• Serious heart, kidney, or liver disease

• Recent ophthalmic surgery (within 6 months) or ocular infection (within 30 days)

• Poorly controlled diabetes or unstable glaucoma