Study of Optimal Posology of Gonadotrophins in Patients With Insufficient Ovarian Response Due to Age

• Status: Withdrawn
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

In In vitro fertilization (IVF) treatment, poor responder patients of more than 38 years old are randomized prospectively into two dosages of gonadotrophins. The outcome of treatment will be analyzed.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Chretien
• Collaborator: EMD Serono
• Treatments: Follicle Stimulating Hormone

Criteria

Inclusion Criteria:

• Women > 38 years with insufficient response to stimulation with 225 IU of gonadotrophins (urinary or recombinant), in an agonist protocol.

• Insufficient response is defined as: development of ≤ 4 mature follicles (of ≥ 16 mm) at time of hCG administration.

• Patient can be eligible for several cycles in same protocol.

Exclusion Criteria:

• Patients who already received doses > 225 IU

• Patients older than 42 years

• Patients with basal FSH concentrations ≥ 15 mU/ml at day 3