Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Status:
Recruiting
Trial end date:
2028-12-01
Target enrollment:
Participant gender:
Summary
Muscle cramps are common in patients with liver disease and associated with significantly
diminished quality of life. Patients with cirrhosis often experience muscle cramps with
varied frequency and severity. The exact mechanisms by which they occur remain unclear,
although a number of pathophysiological events unique to liver disease may contribute.
Clinical studies have identified alterations in 3 areas: nerve function, energy metabolism,
and plasma volume/electrolytes (1) Orphenadrine is an anticholinergic drug with prominent
central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and
other similar conditions. The combination of anticholinergic effects and CNS penetration make
orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and
headaches. [3,4]