Overview

Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis

Status:
Recruiting

Trial end date:
2028-12-01

Target enrollment:
0

Participant gender:
All

Summary

Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity. The exact mechanisms by which they occur remain unclear, although a number of pathophysiological events unique to liver disease may contribute. Clinical studies have identified alterations in 3 areas: nerve function, energy metabolism, and plasma volume/electrolytes (1) Orphenadrine is an anticholinergic drug with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches. [3,4]

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Sherief Abd-Elsalam

Collaborator:

Tanta University

Treatments:

Orphenadrine

Criteria

Inclusion Criteria:

- Cirrhosis

- Muscle cramps( ≥3 cramps per week )

Exclusion Criteria:

- • Allergy to orphenadrine

- Renal impairment

- Pregnant and lactating women

- Peripheral vascular disease

- Peripheral neuropathy

- Medications as calcium channel blockers, conjugated estrogens and naproxen.
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