Study of PET Scans and Serotonin in Hot Flashes Treatment

• Status: Terminated
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine in a preliminary manner whether successful therapy of hot flashes can be associated with changes in the serotonin transporter in the brain. The serotonin transporter is important in delivering serotonin into certain portions of the brains (serotonin is a chemical that is important in the control of body temperature, mood, sleep, and other functions).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
• Treatments: Estrogens; Estrogens, Conjugated (USP); Paroxetine; Serotonin

Criteria

Inclusion Criteria:

• Postmenopausal women

• 7 or more hot flashes per day for at least 3 months

• Must be able to undergo magnetic resonance (MR) and PET imaging

• Must be able to receive either paroxetine or estrogen

Exclusion Criteria:

• No treatment with hormone therapy or other medications that affect estrogen within the past 3 months

• No evidence of a currently active cancer