Study of Pamidronate for the Prevention of Heterotopic Ossification

• Status: Withdrawn
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Bisphosphonates in comparison to radiation therapy are effective in the prophylaxis and treatment of heterotopic ossification in high risk patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Collaborator: FAG (Freie Medizinische Gesellschaft)
• Treatments: Pamidronate

Criteria

Inclusion Criteria:

• Consecutive patients with established HO (Brooker grade III-IV), hospitalized for resection of HO lesions

Exclusion criteria:

• Age <20 years

• Vitamin D deficiency (25OH-Vitamin D <30 ng/ml)

• Renal insufficiency (Clearance <50 ml/min)

• Intolerance of bisphosphonates

• Unable to provide informed consent