Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome

• Status: Completed
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine if testosterone replacement therapy leads to changes in psychological factors and/or motor skills in adolescent males with 47,XXY (also called Klinefelter syndrome). This study will also evaluate whether certain genetic factors of the X chromosome affect the psychological or motor features of XXY/Klinefelter syndrome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborators: Children's Hospital Colorado; Colorado Clinical & Translational Sciences Institute; National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Methyltestosterone; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate

Criteria

Inclusion Criteria:

• Males with 47,XXY

• Participants must be in early puberty (Tanner stage II-III)

• Age 8 - 18 will be considered, but eligibility will be determined by review of laboratory results, bone age X-ray, and physical examination to determine stage of puberty

• All racial and ethnic groups

Exclusion Criteria:

• Other genetic variations of Klinefelter syndrome (48,XXXY, 48,XXYY, 49,XXXXY). The investigator has other studies for these groups and we encourage interested individuals with these disorders to contact us about other available studies.

• 47,XXY plus another genetic disorder

• Non-English speaking individuals (because the psychological tests are administered in English)

• Participants with a medical history of blood clotting problems, blindness, deafness, or cancer