Overview
Study of RMC-6291 in Combination With RMC-6236 in Participants With Advanced KRAS G12C Mutant Solid Tumors
Status:
Recruiting
Recruiting
Trial end date:
2026-11-30
2026-11-30
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study is to evaluate the safety, tolerability, and PK profiles of RMC-6291 and RMC-6236 in adults with KRAS G12C-mutated solid tumors.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Revolution Medicines, Inc.
Criteria
Inclusion Criteria:- 18 years of age
- Histology: pathologically documented, KRAS G12C-mutated, advanced or metastatic solid
tumors not amendable to curative therapy
1. Part 1. Dose Escalation: solid tumors, previously treated
2. Part 2. Dose Expansion:
i. NSCLC, previously treated with immunotherapy, chemotherapy, and KRAS G12C (OFF)
inhibitors, ii. NSCLC, previously treated with immunotherapy and chemotherapy, naïve
to KRAS G12C (OFF) inhibitors, iii. NSCLC, previously treated with immunotherapy,
chemotherapy, with untreated, asymptomatic central nervous system (CNS) metastases <2
cm in size iv. Solid tumors, previously treated, naïve to KRAS G12C (OFF) inhibitors.
- ECOG performance status 0 or 1
- Adequate organ function
Exclusion Criteria:
- Primary central nervous system (CNS) tumors
- Active brain metastases
- Known impairment of GI function that would alter the absorption
- Major surgical procedures within 28 days or non-study related minor procedures within
7 days of treatment