Study of SNX281 in Subjects With Advanced Solid Tumors and Lymphoma

• Status: Recruiting
• Trial end date: 2024-03-18
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial is evaluating a drug called SNX281 given by itself and in combination with pembrolizumab in participants with advanced solid tumors and lymphoma. The main goals of this study are to:

• Find the recommended dose of SNX281 that can be given to participants safely alone and in combination with pembrolizumab.

• Learn more about the side effects and safety profile of SNX281 alone and in combination with pembrolizumab

• Learn more about pharmacological characteristics of SNX281 alone and in combination with pembrolizumab

• Learn more about effectiveness of SNX281 alone and in combination with pembrolizumab

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Silicon Therapeutics; Stingthera, Inc.
• Treatments: Pembrolizumab

Criteria

Inclusion Criteria:

Subjects must meet the following criteria in order to be included in the research study:

1. Written informed consent, according to local guidelines, signed and dated by the subject or by a legal guardian prior to the performance of any study-specific procedures, sampling, or analyses

2. At least 18 years-of-age at the time of signature of the informed consent form (ICF)

3. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1

4. Histological or cytological requirements as follows:

a. Dose Escalation: i. All treatment arms: Subjects with histological or cytological documentation of advanced/recurrent solid tumors or lymphoma who have progressed on, are intolerant of, or are ineligible for existing standard therapies

b. Dose Expansion: i. SNX281 Monotherapy: Subjects with histological or cytological documentation of advanced/recurrent ovarian or colorectal cancer who have progressed on, are intolerant of, or are ineligible for existing standard therapies. Subjects may be checkpoint inhibitor naïve. Subjects who qualify to add pembrolizumab to their treatment regimen, must meet all medical eligibility requirements for receiving pembrolizumab (see Inclusion Criteria 9).

ii. SNX281 in Combination with Pembrolizumab: Subjects with histological or cytological documentation of advanced/recurrent solid tumors or lymphoma who have relapsed on or are refractory to prior checkpoint inhibitor therapy given in an indicated setting. (Note: recruitment may be stopped in a given anatomical indication if no evidence of clinical response is observed in 15 subjects.)

5. Measurable or evaluable disease according to disease-specific tumor assessment criteria. Subjects in dose expansion portions of the study must have at least 1 measurable lesion that has not been previously irradiated, or has progressed after prior irradiation.

6. Adequate organ function, defined as:

a. Hematologic systems i. Absolute neutrophil count (ANC) ≥1.5 × 109/L ii. Hemoglobin ≥9 g/dL iii. Platelets ≥100 × 109/L

b. Hepatic system i. Total bilirubin ≤1.5 × the upper limit of normal (ULN) (for subjects with Gilbert's Syndrome ≤3.0 × ULN [if direct bilirubin ≤35%]) ii. Alanine aminotransferase and aspartate aminotransferase ≤2.5 × ULN; and for subjects with liver metastases ≤5.0 × ULN

c. Renal system i. Estimated glomerular filtration rate (eGFR) by Cockcroft-Gault formula >50 mL/min

d. Cardiac system i. Ejection fraction ≥50% by echocardiogram (ECHO) or multi-gated acquisition (MUGA) scan

7. Male subjects with female partners of childbearing potential and female subjects of childbearing potential are required to use two forms of acceptable contraception, including one barrier method, during their participation in the study and for 3 months following the last dose of SNX281 for male subjects and 6 months following the last dose of SNX281 for female subjects, and for 120 days following the last dose of pembrolizumab for all subjects receiving pembrolizumab. Male subjects must also refrain from donating sperm during their participation in the study and for 3 months following the last dose of SNX281 and 120 days after the last dose of pembrolizumab

8. Life expectancy ≥12 weeks after the start of the treatment according to the Investigator's judgment.

9. Subjects considered for any combination of pembrolizumab and SNX281 must meet, in the opinion of the Investigator, any additional criteria necessary for the safe and proper use of pembrolizumab.

Exclusion Criteria:

Subjects who meet any of the following criteria will be excluded from study entry:

1. Malignancy other than the disease under study with the exception of those from which the subject has been disease-free for more than 2 years and not expected to affect the safety of the subject or the endpoints of the trial. Curatively treated non-melanoma skin cancer is permitted.

2. Symptomatic central nervous system metastases or asymptomatic CNS metastases must be treated and stable for 2 weeks prior to initiation of study treatment. Follow-up scans to confirm stability after 2 weeks are not required. Subjects with carcinomatous meningitis or leptomeningeal spread are excluded regardless of clinical stability.

3. Active autoimmune disease that has required systemic disease modifying or immunosuppressive treatment within the last 2 years. Replacement therapy (e.g., thyroxine or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, insulin for type 1 diabetes, etc.) is permitted.

4. Concurrent medical conditions requiring the use of systemic immunosuppressive treatment within 28 days before the first dose of study treatment. Physiologic doses of corticosteroids (not exceeding 10 mg/day prednisone or equivalent) for treatment of endocrinopathies or steroids with minimal systemic absorption, including topical, inhaled, or intranasal corticosteroids may be continued if the subject is on a stable dose.

5. Current unstable liver or biliary disease per Investigator assessment defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, persistent jaundice, or cirrhosis. Stable chronic liver disease (including Gilbert's syndrome or asymptomatic gallstones) or hepatobiliary involvement of malignancy is acceptable if subject otherwise meets entry criteria

6. History of vasculitis at any time prior to study treatment

7. Evidence or history of significant active bleeding or coagulation disorder that would compromise the subject's ability to adhere to the protocol.

8. Active infection requiring systematic treatment, known human immunodeficiency virus infection (HIV), or positive test for hepatitis B surface (HBs) antigen or hepatitis C virus (HCV).

9. QT interval corrected for heart rate according to Fridericia's formula >480 msec by machine read or human over-read. Pre-existing bundle branch block is permitted at the Investigator's discretion.

10. Recent history (within the past 6 months) of acute diverticulitis, inflammatory bowel disease, intra-abdominal abscess, or gastrointestinal obstruction.

11. Recent history (within 4 weeks of starting study) of allergen desensitization therapy

12. History or evidence of cardiovascular risk including any of the following: recent (within the past 6 months) serious uncontrolled cardiac arrhythmia or clinically significant electrocardiogram (ECG) abnormalities including second degree (Type II) or third degree atrioventricular block; cardiomyopathy, myocardial infarction, acute coronary syndromes (including unstable angina pectoris), coronary angioplasty, stenting, or bypass grafting within the past 6 months before enrollment; congestive heart failure (Class II, III, or IV) as defined by the New York Heart Association functional classification system.

13. Recent (within the past 6 months) history of symptomatic pericarditis

14. History of idiopathic pulmonary fibrosis, interstitial lung disease, organizing pneumonia, or current pneumonitis or a history of non-infection pneumonitis that required steroids. Note: post-radiation changes in the lung related to prior radiotherapy and/or asymptomatic radiation-induced pneumonitis not requiring treatment may be permitted if agreed upon by the Investigator and Sponsor

15. Symptomatic ascites or pleural effusions

16. Any serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with the subject's safety, obtaining informed consent, or compliance with study procedures

17. Prior treatment with the following agents:

• Systemic stimulator of interferon genes (STING) agonist at any time (prior intra-tumoral STING agonist is acceptable)

o Subjects treated in Treatment Arm 1 (SNX281 Monotherapy) who experience disease progression (PD) may be allowed to receive pembrolizumab in combination with SNX281 with Sponsor approval

• Anticancer therapy or investigational therapy within 28 days or 5 half-lives of the drug, whichever is shorter

• PD-1, PD-L1, and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitors within 28 days of the start of study treatment (SNX281 Monotherapy treatment arm only)

• Prior radiation therapy: permissible if at least 1 non-irradiated evaluable lesion is available for assessment according to disease-specific tumor response criteria, or if a solitary evaluable lesion was irradiated, objective progression of that lesion is documented. A washout period of at least 14 days before start of study treatment for radiation of any intended use to the extremities for bone metastases and 28 days for radiation to the chest or visceral organs is required. For radiation to the brain, a washout period of at least 14 days for stereotactic body radiation therapy (SBRT) or stereotactic radiosurgery (SRS) and 28 days for whole brain radiotherapy (WBRT) is required. Palliative radiation is permissible at any other time before or during the study.

• Strong inhibitors and inducers of CYP3A4 must be discontinued 7 days or for a time equivalent to 5-half-lives of the medication (whichever is longer) prior to initiation of SNX281 treatment.

18. Receipt of any live vaccine within 30 days of the start of treatment

19. Prior allogeneic or autologous bone marrow transplantation or other solid organ transplantation

20. Toxicity from previous treatment including toxicity Grade .3 related to prior immunotherapy and that led to study treatment discontinuation; toxicity related to prior treatment that has not resolved to Grade ≤1 (except alopecia, hearing loss, or Grade ≤2 neuropathy or endocrinopathy managed with replacement therapy).

21. Received transfusion of blood products (including platelets or red blood cells) or administration of colony stimulating factors (including granulocyte colony stimulating factor, granulocyte-macrophage colony stimulating factor, and recombinant erythropoietin) within 7 days before the first dose of study treatment.

22. Major surgery ≤28 days before the first dose of study treatment. Subjects must have also fully recovered from any surgery (major or minor) and/or its complications before initiating treatment. Port-a-cath placement is permitted.

23. Active drug or alcohol abuse