Study of Tacrolimus vs Mycophenolate Mofetil in Pediatric Patients With Nephrotic Syndrome
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Primary nephrotic syndrome accounts for approximately 90% of the total number of nephrotic
syndrome in childhood and it is the most common glomerular disease in children. Although
treatment with steroids is uesful for primary nephrotic syndrome, proning to cause frequent
relapse/steroid-dependent nephrotic syndrome after treatment, and the usage of
immunosuppressive agents has become a new choice for the treatment of such patients. This
study is a prospective, randomized, multicenter, open, parallel controlled trial, evaluating
the efficacy and safety of steroid combined with the immunosuppressive agents which are
tacrolimus and mycophenolate mofetil to children who with frequently relapsing or
steroid-dependent nephrotic syndrome, all we wish to obtain the proper drug choice and
individualized treatment options for children with nephrotic syndrome.
Phase:
Phase 4
Details
Lead Sponsor:
The Children's Hospital of Zhejiang University School of Medicine
Collaborators:
Chengdu Women and Children's Center Hospital Children's Hospital of Fudan University First Affiliated Hospital of Zhongshan Medical University Nanjing Children's Hospital Peking University First Hospital Second Xiangya Hospital of Central South University Tongji Hospital