Study of Teclistamab in Combination in Elderly Patients With Multiple Myeloma

• Status: Not yet recruiting
• Trial end date: 2030-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary hypothesis of this study is that SC teclistamab in combination with SC daratumumab or lenalidomide will be safe and induce a high rate of VGPR or better in newly diagnosed multiple myeloma patients

This is an open-label, multicenter, non-comparative, 2-cohort, 2-stage with interruption of enrollment for an efficacy and safety interim analysis, interventional Phase 2 study evaluating the efficacy and safety of a combination with Tec-Dara (Cohort A) or Tec-Len (Cohort B) in patients with newly diagnosed multiple myeloma who are not eligible for SCT.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Lille
• Treatments: Daratumumab; Lenalidomide

Criteria

Inclusion Criteria:

1. Patient must be at least ≥65 years of age at the time of informed consent with documented multiple myeloma as defined by the criteria below:

Multiple myeloma diagnosis according to IMWG diagnostic criteria

Measurable disease at Screening as defined by any of the following:

Serum monoclonal paraprotein (M-protein) level ³ 0.5 g/dL; or Urine M protein level ³ 200 mg/24 hours; or Serum Ig FLC ³ 10 mg/dL and abnormal serum Ig kappa/lambda FLC ratio

2. Have an ECOG performance status score of 0-2

3. Not considered for high-dose chemotherapy and autologous SCT

4. Have clinical laboratory values meeting the criteria during the Screening Phase.

Tec-Dara-specific

5. A male patient must wear a condom when engaging in any activity that allows for passage of ejaculate to another person during the study and for a period of 3 months after receiving the last dose of study treatment. If the male patient's partner is a female of childbearing potential, the male patient must use condoms (with or without spermicide) and the female partner of the male patient must also be practicing a highly effective method of contraception. If the male patient is vasectomized, he still must wear a condom (with or without spermicidal foam/gel/film/cream/suppository), but his female partner is not required to use contraception. A male patient must agree not to donate sperm for the purpose of reproduction during the study and for a period of 3 months after receiving the last dose of study intervention.

6. Must sign an ICF (or their legally acceptable representative must sign in accordance with local requirements) indicating that the patient understands the purpose of, and procedures required for, the study and is willing to participate in the study.

7. Must be willing and able to adhere to the lifestyle restrictions specified in this protocol.

Exclusion Criteria:

Medical Conditions

1. CNS involvement or clinical signs of meningeal involvement of multiple myeloma. If either is suspected, negative whole brain MRI and lumbar cytology are required.

2. Plasma cell leukemia, Waldenström's macroglobulinemia, POEMS syndrome or primary light chain amyloidosis.

3. Myelodysplastic syndrome or active malignancies.

4. Stroke, transient ischemic attack, or seizure within 6 months prior to signing ICF.

5. Presence of a cardiac conditions.

Tec-Dara-specific

6. COPD with a FEV1 <50% of predicted normal. Note that FEV1 testing is required for patients with known or suspected of having COPD or asthma and patients must be excluded if FEV1 <50% of predicted normal.

7. Moderate or severe persistent asthma within the past 2 years or uncontrolled asthma of any classification. Note that FEV1 testing is required for patients known or suspected asthma and patients must be excluded if FEV1 <50% of predicted normal.

Prior/Concomitant Therapy

8. Radiotherapy within 14 days or focal radiation within 7 days.

9. Received a cumulative dose of corticosteroids equivalent to ≥140 mg of prednisone within 14-days before the first dose of study drug (does not include pretreatment medications).

10. Received live or live-attenuated vaccine(s) within 4 weeks prior to screening or plans to receive such vaccines during the study. Vaccines approved or authorized for emergency use (eg, COVID-19) and non-live vaccines (eg, influenza) are allowed.

11. Any prior therapy for multiple myeloma or smoldering myeloma other than a short course of corticosteroids (not to exceed 40 mg of dexamethasone, or equivalent per day for a maximum of 4 days, total of 160 mg dexamethasone or equivalent.

12. Contraindications or life-threatening allergies, hypersensitivity, or intolerance to any study drug or its excipients.

Diagnostic Assessments

13. HIV positive.

14. Hepatitis B infection.

15. Active hepatitis C infection as measured by positive HCV-RNA testing. Other Exclusions

16. Patient had major surgery or had significant traumatic injury within 2 weeks prior to the start of administration of study treatment, or will not have fully recovered from surgery., or has major surgery planned during the time the patient is expected to be treated in the study or within 2 weeks after administration of the last dose of study treatment.

17. Concurrent medical or psychiatric condition or disease that is likely to interfere with study procedures or results.

18. Patient plans to father a child while enrolled in this study or within 3 months after the last dose of study intervention.

19. Person under guardianship, trusteeship or deprived of freedom by a judicial or administrative decision.