Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT)

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine the Pharmacokinetics/Pharmacodynamics(PK/PD) of tigecycline in critical ill patients undergoing continuous renal replacement therapy（CRRT）and examine whether the dosage needs adjustment.

The study will observe two groups of patients respectively and compare the difference between them. Patients who need to receive CRRT when treat with high-dose tigecycline will be collected in Group CRRT. Patients who treat with high-dose tigecycline only will be collected in Group non-CRRT.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhujiang Hospital
• Treatments: Minocycline; Tigecycline

Criteria

Inclusion Criteria:

• Aged 18-75 years,hospitalized ICU patients, male or female;

• having definitive diagnosis to treat with tigecycline for bacterial infection;

• receiving CRRT with renal insufficiency or not receiving CRRT with normal renal function.

Exclusion Criteria:

• Patients with Child-Pugh C cirrhosis;

• Allergic to tetracycline or tigecycline;

• Patients received CRRT for < 3 days or treated with tigecycline < 3 days;

• Patients who are pregnant.