Study of Topically Applied Green Tea Extract for Radio Dermatitis and Radiation Mucositis
Status:
Enrolling by invitation
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
Radiodermatitis and radiation mucositis were the most frequent side-effect during the course
of radiotherapy, especially when concurrent chemoradiotherapy applied. Since reactive oxygen
species formed upon radiation therapy play a central role in initiating and driving the
detrimental signaling events, antioxidant supplementation is thought to provide a
photoprotective effect against radiation. Green tea extract has been shown to have
antioxidant and anti-inflammatory effects on various types of cells. To evaluate the safety
and efficiency of green tea extract in the treatment of radio dermatitis and radiation
mucositis, the investigators conducted this phase Ⅰ,II study using topical EGCG in cancer
patients receiving radiotherapy or concurrent chemoradiotherapy .