Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Many types of cancer are primarily treated with surgery and patient survival is directly
related to the extent to which the tumor is able to be removed. It is often difficult for
surgeons to distinguish tumor tissue from normal tissue or to detect tumor cells that have
spread from the original tumor site, resulting in incomplete removal of the tumor and reduced
patient survival. In some sites, such as the brain, it is critical to avoid damage to normal
tissue around the tumor to prevent adverse effects of surgery on function. Tozuleristide is a
drug that is thought to attach to tumor tissue and then fluoresces (glows) when a special
light from the Canvas is shined on it. It is hypothesized that tozuleristide, when imaged
with the Canvas, will improve surgical outcomes by allowing surgeons to visualize the edges
of the tumor or other ambiguous tissue in real-time as they operate. The purpose of this
study is to evaluate how well tozuleristide imaged with Canvas work at helping to distinguish
between tumor and normal tissue during surgery in pediatric primary central nervous system
tumors.