Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching

• Status: Terminated
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is determine if long acting antihistamine like cetirizine can help with itching induced by opioid pain medications.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Virginia Commonwealth University
• Treatments: Cetirizine; Histamine Antagonists; Histamine H1 Antagonists

Criteria

Inclusion Criteria:

• Children age 6-18yrs on opioids who develop pruritus and are willing to participate in the study

Exclusion Criteria:

• Children with history of chronic urticaria

• Children with other chronic pruritic condition like eczema, contact dermatitis, psoriasis

• Children with known hypersensitivity to cetirizine/zyrtec

• Children on H1 antihistamine like diphenhydramine, hydroxyzine, cetirizine, loratadine, fexofenadine, chlorpheniramine within the last 7days prior to randomization

• Children who have received Ondansetron within 24hrs prior to randomization

• Children who are on Tricyclic antidepressants

• Children who are unwilling or unable to swallow the capsule.

• Children with chronic liver or kidney disease