Study of Whether 15 mg Dose of Ketorolac IV is as Effective as a 30 mg Dose.

• Status: Unknown status
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this study is to show the non-inferiority of 15 mg intraoperative dose of ketorolac as compared to the standard 30 mg ketorolac by looking at the VAS scores 4 hours after an adult spine surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Calgary
• Treatments: Anti-Inflammatory Agents, Non-Steroidal; Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• Patients booked for 1-2 level spine laminectomies and/or decompression

• Adult 18 - 65 years

• Weight of 50 - 110 kg

Exclusion Criteria:

• Previous lumbar laminectomy

• Current anticoagulant use with INR > 1.2

• Narcotic use > 4 weeks

• Known allergy or sensitivity to NSAID or morphine

• Renal insufficiency with creatinine >100 umol/L

• Known liver disease

• History of gastrointestinal bleeding

• Pregnancy, history of bronchial asthma

• NSAID use 2 days before surgery.