Study of Whole-brain Irradiation With Chloroquine for Brain Metastases

• Status: Terminated
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Background and purposes:Chloroquine (CLQ), an antimalarial drug, has a lysosomatrophic effect associate with increase the sensibility of Radiation through leakage of hidroliticenzimes, increase of apoptosis, autophagy mediated by lysosomalhidrolases and increase of oxidative stress "in vitro". In this phase II study we evaluated the efficacy and safety as radiosensitizing of the Chloroquine plus concomitant 30 Gray (Gy) of Whole-brain irradiation (WBI)in patients with brain metastases (BM) from solid tumors.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Cancerologia de Mexico
• Treatments: Chloroquine; Chloroquine diphosphate

Criteria

Inclusion Criteria:

• 18 to 80 years of age

• At leat one brain metastasis MRI

• KPS 70 or more

• RTOG-RPA I or II

• Basic Laboratory requirements

Exclusion Criteria:

• Candidates for radiosurgery, neurosurgery

• Patients treated with radiotherapy before entered to the study