OBJECTIVES: I. Establish the safety and efficacy of extended maintenance zinc therapy in 200
patients with Wilson disease.
II. Establish further the role of zinc in the prophylactic treatment of presymptomatic
patients by increasing the current cohort from 80 to at least 100 patients.
III. Establish further the role of zinc therapy in pregnant patients with Wilson disease.
IV. Establish further the role of zinc therapy in children with Wilson disease.