Study of the Ability of Betaine Hydrochloride to Increase Stomach Acid in Healthy Volunteers

• Status: Completed
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study the investigators will test a nutritional supplement called betaine hydrochloride to see if it can temporarily increase the stomach acid in healthy volunteers who have decreased stomach acid because they take a medicine called rabeprazole.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Betaine; Rabeprazole

Criteria

Inclusion Criteria:

• Healthy adult with no active medical problems or significant chronic diseases as determined by the study doctor based on history, physical exam;

• BMI between 18.5 - 35 kg/m2;

• Taking no medications 2 weeks before and during the study enrollment, including drugs of abuse, prescription or OTC medications (except acetaminophen);

• Subjects must be able to maintain adequate birth control during the study independent of hormonal contraceptive use;

• Be able to provide written informed consent and comply with requirements of the study;

• Avoid eating grapefruit and drinking grapefruit juice from 7 days before the first study day until completion of the entire study;

• Abstinence from alcoholic beverages, caffeinated beverages and orange juice from 6pm the night before a study day until completion of that study day;

• Fast from food and beverages at least 8 hours prior to the study day;

• Be able to read, speak and understand English

Exclusion Criteria:

• Subjects with a history of gastrointestinal disease including gastroesophageal reflux disease, gastritis, peptic ulcer disease or dyspepsia.

• Subjects with a fasting gastric pH of > 4 (i.e. hypochlorhydria)

• Subjects with history of dysphagia, achalasia, or difficulty swallowing capsules, tablets or pills.

• Subjects on prescription or chronic over-the counter medications (including hormonal contraceptives);

• Subjects with known allergy to study interventions;

• Subjects who smoke tobacco;

• Subjects with ongoing alcohol or illegal drug use;

• Subjects who are pregnant, lactating or attempting to conceive;

• Subjects unable to maintain adequate birth control during the study;

• Subjects unable to follow protocol instructions or protocol criteria.